Expert Regulatory Toxicology for High-Risk Decisions
Resources and Tools
Follow a scientific team's decision-making as it evaluates a newly detected trace impurity, from initial signal to risk conclusion.
Classify a trace impurity, then derive its acceptable intake and phase-appropriate control limits. Free public artifact.
Classify a trace impurity, then derive its acceptable intake and phase-appropriate control limits. Free public artifact.
Evaluate excipients before treating prior use as a safety justification. Enter a formulation and calculate daily excipient exposure,
2027 DABT Certification Exam Countdown!
Prepare for the October 2027 Diplomate of the American Board of Toxicology (DABT) exam - let's make preparations. Don’t miss out!
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2026 Examination Information
2026 Examination Information
2026 Examination Information
Learn more about the American Board of Toxicology (ABT) exam.
DABT Exam Domain Weighting
2026 Examination Information
2026 Examination Information
See the five weighted knowledge domains covered on the exam.
View Exam Resources
2026 Examination Information
View Exam Resources
See the curated list of books, guidances, and publications.
From American Board of Toxicology (ABT) Website for 2026:
2026 Exam Scheduling and Administration
2026 Exam Scheduling and Administration
2026 Exam Scheduling and Administration
The ABT exam is held once per year at testing centers throughout the world and administered via computer. Details are available on the Pearson VUE website. NOTE: Until Pearson updated the ABT page on their site to include a tab called Seat Availability, the site listings are not accurate. The examination is 4 hours in length and consists of 160 questions delivered in a four-hour time block. Of the 160 questions, 140 are scored, and 20 are pre-test, unscored items. The candidate will not be told which items are not scored. The exam is graded as a whole for a single score. An applicant may take the exam in any of the three years.
Testing Centers
2026 Exam Scheduling and Administration
2026 Exam Scheduling and Administration
Pearson VUE administers the ABT exam at test centers worldwide. Candidates must appear in person; there is no option for online testing with virtual proctors. While Pearson VUE has more than 4500 testing sites, the ABT exam (text cut off at the bottom of the image).
Note: the original document's "here" hyperlink target was not visible in the image, so I used the Pearson VUE ABT landing page. Send the next page if you want the cut-off sentence completed.
2016 DABT Examination Domain Weight
Toxicology References
Books
US EPA Risk Assessment Guidelines
US FDA Guidance for Industry
- Klaassen, C.D., Ed.: Casarett and Doull's Toxicology: The Basic Science of Poisons. 9th Edition, McGraw-Hill (2018). [Amazon]
- Hayes, A.W., Ed.: Hayes' Principles and Methods of Toxicology. 7th Edition, CRC Press (2023).
- Torres, J. and Bobst, S. (eds.). Toxicological Risk Assessment for Beginners, Springer (2015).
- Gilman, A.G., Rall, T.W., Nies, A.S. and Taylor, P., Eds.: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (2017).
US FDA Guidance for Industry
US EPA Risk Assessment Guidelines
US FDA Guidance for Industry
- The Least Burdensome Provisions: Concept and Principles. Guidance for Industry and Food and Drug Administration Staff. CDRH/CBER, February 2019 (FDA PDF).
- Guidance for Industry: Nonclinical Studies for the Safety Evaluation of Pharmaceutical Excipient. CDER/CBER, May 2005 (FDA PDF).
- Frequently Asked Questions about GRAS for Substances Intended for Use in Human or Animal Food, Guidance for Industry. October 2016 (FDA PDF).
- Toxicological Principles for the Safety Assessment of Food Ingredients: Redbook 2000, July 2007 (FDA Redbook 2000).
- Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. Guidance for Industry. Pharmacology and Toxicology, July 2005 (FDA PDF).
- Safety Testing of Drug Metabolites. Guidance for Industry. Pharmacology and Toxicology, March 2020 (FDA PDF).
- Carcinogenicity Study Protocol Submissions. Guidance for Industry. Pharmacology and Toxicology, May 2022 (FDA PDF).
US EPA Risk Assessment Guidelines
US EPA Risk Assessment Guidelines
OECD Guidelines for the Testing of Chemicals
- Risk Assessment Guidance for Superfund (RAGS): Part A (EPA RAGS Part A).
- Guidelines for Carcinogen Risk Assessment (EPA carcinogen guidelines).
- Guidance for Applying Quantitative Data to Develop Data-Derived Extrapolation Factors for Interspecies and Intraspecies Extrapolation (EPA DDEF PDF).
OECD Guidelines for the Testing of Chemicals
OECD Guidelines for the Testing of Chemicals
OECD Guidelines for the Testing of Chemicals
- Human Health Effects (Section 4) Test Numbers 408, 413, 414, 420, 432, 437, 438, 442, 443, 471, 492, and 497 (OECD Section 4: Health Effects).
- Effects on Biotic Systems (Section 2): Test Numbers 202, 203, and 207 (OECD Section 2: Effects on Biotic Systems).
National Research Council (NRC) publications
OECD Guidelines for the Testing of Chemicals
National Research Council (NRC) publications
- National Research Council (NRC). Science and Decisions: Advancing Risk Assessment (Silver Book). National Academy Press, Washington, D.C., 2009 (NAP catalog).
- National Research Council of the National Academies of Science. 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy (2007). Washington, DC: The National Academies Press (NAP catalog).
ICH and VICH Guidelines for Pharmaceuticals
OECD Guidelines for the Testing of Chemicals
National Research Council (NRC) publications
Safety (S), Quality (Q3 Impurities), and Multidisciplinary (M3, M4, M7) (ICH guidelines).
ToxVeritas
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